The joint-local renin-angiotensin system in rheumatoid arthritis and osteoarthritis: mechanistic evidence, disease-specific patterns, and translational perspectives.

Rheumatol Int · 2026 · PMC12876080 · PMID 41642365

Europe PMC DOI

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a numerical trendno p-value reported

did not reach statistical significanceno p-value reported

Notably, although the pooled analysis did not reach statistical significance, the meta-analysis showed a numerical trend toward increased risk (OR 1.37) accompanied by very high between-study heterogeneity (I2 = 87.2%).

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