One trial suggested a possible trend of reduced responses among African American adolescents receiving sibutramine, although the findings were underpowered and exploratory.
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Systematic review of influence of ethnicity on efficacy and safety of pharmacotherapy for childhood and adolescent obesity.
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The sentences
The sibutramine trial, the only study explicitly designed to compare outcomes of African American and Caucasian adolescents, suggested a potential differential pattern: Caucasian adolescents receiving sibutramine plus behavioral therapy had significantly greater weight and BMI reductions than those receiving behavioral therapy plus placebo, whereas African American adolescents showed numerically greater weight loss with sibutramine than placebo, but the difference did not reach statistical significance, likely reflecting limited power in the smaller African American subgroup [ 52 ].