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Use of biomarkers to select the target population for clinical trials in subjects with mild cognitive impairment.

J Nutr Health Aging · 2009 · PMC12877482 · PMID 19300874

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One trial showed an effect of donepezil on cognition after 24 weeks ( 4 ), while the other trials failed to reach statistical significance on the primary endpoint ( 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.