Synergistic effects of anticoagulants and platelet aggregation inhibitors with immune checkpoint inhibitors in cancer therapy: a comprehensive review of preclinical and clinical evidence.

The meta-analysis by Xiong et al also reported a trend toward improved PFS and OS in patients treated with Fr Xa inhibitors, although the results did not reach statistical significance. 51 These findings are in line with the observation of Haist et al of a synergistic effect between ICI and FXa inhibition. 42 These findings highlight the need for prospective (randomized) clinical studies particularly focusing on FXa inhibitors to validate and explore the potential of concomitant AC to ICI.

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