The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial.

The experimental intervention resulted in a significant elevation of brain total choline (tCho) levels at two locations (left and right paracentral grey matter) during the trial ( P ≤ 0.05); a strong trend for a non-significant increase was observed at the left frontal white matter, left parietal white matter, and right parietal mesial grey matter ( P ≤ 0.20).

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