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Neuropsychiatric Features in Patients With Idiopathic Normal Pressure Hydrocephalus: A Systematic Review and Meta-Analysis.

Neurol Clin Pract · 2026 · PMC12879024 · PMID 41657358

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→ CSF shunting may reduce depressive symptoms postoperatively; however, the meta-analysis of this effect (pooled effect size −0.30) did not reach statistical significance. → The current evidence base is limited by low study quality and significant heterogeneity, highlighting a critical need for more methodologically rigorous research into the neuropsychiatric aspects of iNPH.

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