Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML.

TP53-mutated cells showed a trend toward higher GPX4 expression and higher levels of the iron-storage protein FTL, weaker induction of lipid peroxidation after RSL3 exposure, and higher IC50 values for RSL3 at 24 and 48 h, consistent with reduced ferroptosis sensitivity (Fig. 3 L–N).

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