Circulating inflammatory proteins predict dementia risk, and are linked to structural brain changes and modifiable risk factors.

Mendelian Randomisation In two-sample MR analyses, we identified nominally significant inverse associations for tumour necrosis factor ligand superfamily member 13 (TNFSF13) with both AD (β = −0.094, se = 0.04, p = 0.012) and ACD (β = −0.104, se = 0.04, p = 0.013), and for interleukin (IL)−17D with ACD (β = −0.071, se = 0.03, p = 0.032; (Supplementary Table 9).

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