Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study.

J Nutr Health Aging · 2009 · PMC12880342 · PMID 19536424

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.1500

boldest claim

The sentences

marginally non-significantP = 0.071so close (0.05 < p ≤ 0.1)

Placebo) were observed at Weeks 26 (P = 0.016) and 52 (P = 0.041), as well as marginally non-significant differences at Weeks 13 (P = 0.071) and 39 (P = 0.064).

also in 978 other papers

a statistical trendP < 0.15not close (p > 0.1)

Second, bivariate analyses were used to identify variables which were predictors of outcome based on a statistical trend defined as a P < 0.15.

also in 1,557 other papers

highly significantno p-value reported

A highly significant site effect, large between- and within-patient variation and poor fit of the data rendered the analyses produced from the First models inconclusive and a second modelling approach was implemented ( 22 ).

also in 82,236 other papers

marginally significantno p-value reported

Moreover, there was a marginally significant overall treatment main effect and a significant slope difference in favour of tramiprosate according to the Final model analysis of the ADAS-cog scores.

also in 14,984 other papers

did not reach statistical significanceno p-value reported

Results Psychometric score results showed numerical trends in favour of tramiprosate that did not reach statistical significance.

also in 75,278 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.