GSEA identified a highly significant enrichment for stemness, adaptive immunity features in young vaccine recipients, and innate lymphocyte immunity in older vaccine recipients ( Fig. 3, F and G ).
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Antigen-specific T<sub>H</sub>17 cells offset the age-related decline in durable T cell immunity.
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The PCA of the most variable transcripts showed a trend toward separation of Zostavax and Shingrix recipients for VZV gE–specific CD4 + T cells (fig.