Additive effect of multiple genetic variants in <i>SEC23B</i> and <i>PIEZO1</i> on iron metabolism dyshomeostasis in hereditary anemias.

NextGenerationEU and Italian Ministry of Research CN00000041 Most notably, a strong and highly significant positive correlation emerged between CVS and ferritin Z ‐score ( r = 0.707; P < 0.0001), highlighting a robust association between increased mutational load and elevated ferritin levels, independent of age and gender (Figure 1C ).

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Accordingly, the ferritin/age ratio was higher in dual‐diagnosis patients compared to CDA II patients, with a borderline significant P‐value (P = 0.05, Mann–Whitney test) (Table 2 ).

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Although Hb levels were slightly higher in the dual‐inheritance group, this difference did not reach statistical significance.

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