Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease.

J Transl Med · 2026 · PMC12882428 · PMID 41519805

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

In mice treated with V/Cp-LPP/shSmad3 and V/Cp-LPP/shRunx2, ALP activity in the aortic valves was reduced by approximately 30%, though the change did not reach statistical significance (Fig. 3 B).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.