Guiling prescription attenuates hyperuricemia via multi-target regulation of uric acid metabolism, renal protection, and inflammation: insights from metabolomics and network pharmacology.

A notable trend toward normalization was observed following treatment with GP, indicating that GP effectively improves the disruption of the pentose phosphate pathway caused by HUA.

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In this study, an increase in uracil levels was detected in the Mod group, indicating a disorder in pyrimidine metabolism in HUA rats, with a significant trend toward normalization following treatment.

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Treatment with benzbromarone and Simiao pill significantly reduced serum IL-6 levels ( P < 0.01), while allopurinol showed a decreasing trend in IL-6 levels, though the difference was not statistically significant.

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