Design, synthesis and biological evaluation of novel KRAS-G12D inhibitors.

J Enzyme Inhib Med Chem · 2026 · PMC12884991 · PMID 41645749

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did not reach statistical significanceno p-value reported

Importantly, the differences in ΔG values between GD-2 and GD-4 did not reach statistical significance, as the error bars (±2–3 kcal/mol) from replicate sampling overlapped considerably.

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