Alcohol consumption and mortality among stroke survivors: A NHANES observational cohort study with mediation analysis.

Medicine (Baltimore) · 2026 · PMC12885667 · PMID 41650044

Europe PMC DOI

hedged sentences

0.0533

closest p · 1.1× alpha

0.0833

boldest claim

The sentences

approached significanceP = .0533so close (0.05 < p ≤ 0.1)

Notably, PLR showed a significant direct effect (HR = 1.0490, P = .0267), and the NLR + PLR + NPAR combination approached significance ( P = .0533), suggesting partial but weak direct associations, not mediated through inflammatory pathways.

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a possible trendP = .0833so close (0.05 < p ≤ 0.1)

For heavy drinking, the HRs across all models were not statistically significant, although Model 3 suggested a possible trend toward lower risk (HR = 0.707; 95% CI: 0.48–1.05; P = .0833).

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