showed a trendp = 0.083
While the univariate analysis (Table 2 ) showed a trend toward a difference in the environmental domain at 12 months (early 75.2 [15.8] versus late 71.4 [15.2], p = 0.083), it was not statistically significant in the multivariate mixed model (Table 3 ; early 80.1 [95% CI: 73.9 to 86.2] versus late 74.7 [95% CI: 68.5 to 80.9], p = 0.209).