Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease.

Front Oncol · 2025 · PMC12886026 · PMID 41675514

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did not reach statistical significanceno p-value reported

Importantly, in normal fetal human colon (FHC) cells, 1H5 treatment resulted in modest changes in Alamar Blue signal that did not reach statistical significance and lacked the dose-dependent suppression observed in colorectal cancer cell lines ( Supplementary Figure 1 ), supporting a preferential effect of 1H5 on cancer cells.

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