Sea cucumber protein hydrolysate restores the Th1/Th2 paradigm in cyclophosphamide-induced immunosuppressed mice.

GATA3 expression showed a trend toward upregulation in the CYP and CPL groups compared with NC; SCPH did not significantly change GATA3 levels but showed an apparent trend toward downregulation relative to CYP, as illustrated in Figures 5A –D, consistent with the reciprocal regulation of TBX21 and GATA3 in Th1/Th2 balance. 3.4 SC

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GATA3 expression showed a trend toward upregulation in the CYP and CPL groups compared with NC; SCPH did not significantly change GATA3 levels but showed an apparent trend toward downregulation relative to CYP, as illustrated in Figures 5A –D, consistent with the reciprocal regulation of TBX21 and GATA3 in Th1/Th2 balance. 3.4 SCPH rebalances the Th1/Th2 serum cytokines and immunoglobulin production Serum levels of Th1-associated cytokines (IFNG, IL1B) and Th2-associated cytokines (IL4, IL10) were quantified using highly sensitive double-antibody sandwich ELISAs, and IgG, IgM, and IgA concentrations were measured by inverse antigen competitive ELISA.

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