Pro-inflammatory response of human iPSC-derived intestinal epithelial monolayers towards microbial toxins LPS and nigericin.

Arch Toxicol · 2026 · PMC12886239 · PMID 41060467

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showed a trendno p-value reported

Exposure of iPSC-derived IEC monolayers to increasing concentrations of nigericin in the presence of 100 ng/mL LPS showed a trend of increased release of IL-6, IL-8, and TNF-α (Fig. 3 a, c, e), whereas basolateral exposure to the highest concentration of nigericin caused a statistically significant effect.

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