Psychosocial impact of COVID-19 pandemic on patients with solid malignancies and bone metastases (PsyCO-B): a multicentre prospective observational study.

J Bone Oncol · 2026 · PMC12886513 · PMID 41674726

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.5740

boldest claim

The sentences

a trend towards significancep = 0.074so close (0.05 < p ≤ 0.1)

However, the interaction between clinical severity and psychological impact of COVID-19 showed a trend towards significance (F 1,115 = 3.245, p = 0.074), indicating that the link between the traumatic impact of the pandemic and depression may vary depending on clinical severity, although it did not reach robust statistical significance ( Table 2 ).

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did not reach statistical significancep = 0.574not close (p > 0.1)

Similarly, the total effect of BIPQ_TOT on HADS-D (i.e., the sum of direct and indirect effects) did not reach statistical significance (β = 0.122, SE = 0.217, z = 0.574, p = 0.574, 95% CI [-0.303, 0.547]).

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