A machine learning-defined cellular senescence signature systematically enhances prognostication and guides immunotherapy strategies for the treatment of gliomas.

NPJ Precis Oncol · 2026 · PMC12886967 · PMID 41501133

Europe PMC DOI

hedged sentence

0.7430

closest p · 14.9× alpha

0.7430

boldest claim

The sentences

did not reach statistical significancep = 0.743not close (p > 0.1)

In a multivariate Cox model including CSRGPS, IDH, and their interaction term, the interaction term (CSRGPS × IDH) did not reach statistical significance (HR = 0.95, 95% CI: 0.71–1.27, p = 0.743), indicating that the prognostic role of CSRGPS is independent of IDH status (Supplementary Fig.

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