Health-related quality of life in adults with von Willebrand disease: results of the French real-life Willebrand study on health-related quality of life.

Potential confounding factors Although iron deficiency’s potential impact on PROs was not analyzed due to the low prevalence of abnormal hemoglobin levels (4.5% of the cohort), patients receiving iron supplementation ( n = 53) showed a trend toward lower SF-36 mental scores (mean MCS, 42) than untreated patients ( n = 133; mean MCS, 45; P = .07).

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No significant gender-based differences in SF-36 scores were detected in the 18- to 50-year age group, although a nonsignificant trend indicated that women scored lower the vitality dimension, as well as in the aggregate MCS.

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