Integrating CAR-T therapy with PD-1/PD-L1 blockade: Mechanisms, synergy, and optimized strategies in NSCLC.

While other immunosuppressive molecules, such as TIGIT, were simultaneously upregulated, these changes did not reach statistical significance. 55 These findings suggest that, in certain patients with acquired resistance to PD-1/PD-L1 blockade, compensatory upregulation of LAG-3 and, to a smaller extent, TIM-3 may occur during treatment.

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