Distinct roles for SETα and SETβ in early cell fate decisions.

Nucleic Acids Res · 2026 · PMC12887537 · PMID 41665009

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closest p · 0.0× alpha

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highly significantP = 2.6 × 10 -63actually significant

However, these overlaps were highly significant relative to a genomic background composed of 1-kb bins (Fisher’s exact test, P = 2.6 × 10 -63 for SETα; P = 1.9 × 10 -45 for SETβ), suggesting that SET isoforms are nonrandomly associated with ETV5-bound regulatory loci.

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a significant trendP = .025actually significant

In a SET-KO background, SETα addback was associated with a significant trend towards activation ( P = .025) but no significant repressive function ( P = .201).

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