Time-dependent Lactiplantibacillus plantarum (LP) AS21 intervention enhances mesalazine efficacy by modulating gut microbiota and host immunometabolic responses in DSS-induced colitis.

J Transl Med · 2026 · PMC12888428 · PMID 41530722

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closest p · 1.2× alpha

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boldest claim

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a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

which were markedly reduced by LP AS21-augmented MSA treatment, with significant MPO reduction in S_MSA and T_MSA groups ( p < 0.05), and a strong trend toward MDA reduction in T_MSA ( p = 0.06).

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