Genetic diversity in melanomagenesis: a comprehensive analysis of BRAF, NRAS, KIT and novel mutations across melanoma subtypes.

BMC Cancer · 2025 · PMC12888517 · PMID 41408518

Europe PMC DOI

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0.4780

closest p · 9.6× alpha

0.4780

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did not reach statistical significanceP = 0.478not close (p > 0.1)

Among 43 cutaneous melanomas (including nodular, superficial spreading, acral lentiginous, and lentigo maligna subtypes), BRAF mutations were detected in 12 cases (27.9%), while mucosal melanomas ( n = 12) harbored BRAF mutations in only 2 cases (16.7%), though this difference did not reach statistical significance ( P = 0.478, Fisher’s exact test).

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