Quantifying the impact of tumor size and motion on 4DCT-4DCBCT image registration accuracy using machine learning and statistical analysis.

J Appl Clin Med Phys · 2026 · PMC12888845 · PMID 41665480

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did not reach statistical significancep > 0.05actually significant

highly significantno p-value reported

The multifactor ANOVA further supported these findings, demonstrating that tumor size ( p < 0.001) and SI motion ( p < 0.001) have a highly significant influence on registration quality, whereas the respiratory cycle and AP/LR motions did not reach statistical significance ( p > 0.05).

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