IKAROS LOF variants acting through DN, HI, or DD mechanisms exhibited significantly reduced suppression of HNRNPLL transcriptional activity when compared with WT IKAROS; on the other hand, GOF variants showed a trend of enhanced suppression activity when compared with the WT control, although this was not statistically significant ( Figure 2E ).
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IKAROS regulates human T cell phenotype at a thymic and postthymic level.
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