Prospective SARS-CoV-2 additional vaccination in immunosuppressant-treated individuals with autoimmune diseases in a randomized controlled trial.

While increases in the humoral response did not differ statistically between participants who withheld their medication and those who did not in both the MMF/MPA ( P = 0.79) and MTX cohorts ( P = 0.16), there was a numerical trend toward higher geometric mean concentrations in participants who withheld therapy ( Supplemental Table 2 ).

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While we observed a numerical trend toward an increased humoral response in patients who withheld MMF/MPA or MTX around the time of vaccination, the difference did not reach statistical significance, and no safety concerns were identified.

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