Endocrine regimen and early subclinical atherosclerosis in premenopausal HR+/HER2- breast cancer: real-world evidence and regimen-dependent effects of Sanhuang Decoction.

Front Oncol · 2026 · PMC12890639 · PMID 41684590

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

close to significanceP = 0.053so close (0.05 < p ≤ 0.1)

For new-onset carotid plaque, the AI+OFS regimen showed a higher, though not statistically significant, hazard compared with TAM (HR 3.087; 95% CI, 0.960–9.930; P = 0.059), and baseline HbA1c was similarly close to significance (HR 2.579; 95% CI, 0.987–6.741; P = 0.053).

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showed a trendno p-value reported

AI+OFS showed a trend toward a higher hazard of new-onset carotid plaque versus TAM (hazard ratio [HR] 3.09; 95% CI 0.96–9.93), and higher baseline glycated hemoglobin predicted earlier initiation of lipid-lowering therapy (HR 2.54; 95% CI 1.29–4.99).

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