Large-scale DNA organization analysis of primary breast cancers for prediction of axillary lymph node metastases.

Although the combined model's AUC improvement over clinicopathology alone (ΔAUC = +0.03, p = 0.16 by DeLong test, Supplementary Table 6 ) did not reach statistical significance, it consistently provided superior calibration and clinical utility across validation and external test sets compared to the other models ( Supplementary Table 4 ).

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