Elevated cerebral oxygen extraction fraction in Parkinson's disease correlates with motor impairment severity.

Sci Rep · 2026 · PMC12891709 · PMID 41549084

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did not reach statistical significancep < 0.1so close (0.05 < p ≤ 0.1)

a positive trendno p-value reported

OEF in the putamen also showed a positive trend with UPDRS-III (ρ = 0.288), but this did not reach statistical significance, indicating a marginal relationship ( p < 0.1).

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marginal significanceno p-value reported

Similar significant increases in OEF were observed in the RN ( p = 0.048, t(78) = 2.01, d = 0.46), GP ( p = 0.044, t(78) = 2.02, d = 0.47) and putamen ( p = 0.048, t(78) = 2.01, d = 0.46) with CN ( p = 0.07, t(78) = 2.03, d = 0.42) and WM ( p = 0.10, t(78) = 1.66, d = 0.38) showing marginal significance, although effect sizes were moderate (Supplementary Table 1 ).

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