GLP-1 Receptor Agonists Plus Progestins and Endometrial Cancer Risk in Nonmalignant Uterine Diseases.

JAMA Netw Open · 2026 · PMC12892152 · PMID 41665904

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A smaller pilot study also showed a trend toward improved response with metformin, despite limited sample size. 25 Collectively, these studies suggest that adding metformin to progestin therapy may improve histologic response and reduce recurrence risk.

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