Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind Clinical and In Vitro Study.

J Cosmet Dermatol · 2026 · PMC12892161 · PMID 41669823

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did not reach statistical significanceno p-value reported

Although other differences did not reach statistical significance, a consistent trend toward higher ECM gene expression was observed in fibroblasts treated with CaHA + PMN relative to CaHA + SS. 3.3.

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