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MiRNAs in Interstitial Skin Fluid Sampled with Swellable Hydrogel Microneedles Are Locally Deregulated Near Malignant Skin Lesions in Early Stages of Cutaneous Squamous Cell Carcinoma.

ACS Biomater Sci Eng · 2026 · PMC12892239 · PMID 41566787

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Above 4-fold upregulation of all four miRNAs was observed in skin fluid of cancer mice compared to healthy controls, with strong or near statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.