When Familiar Faces Feel Better: A Framework for Social Neurocognitive Aging in a Rat Model.

On the social novelty trial, baseline (pretreatment) social novelty index scores revealed a marked trend toward a social familiarity preference in the aged group, confirming the pattern observed in Experiment 1 ( Fig. 6 A ). iTBS had no effect on social novelty in either the young or aged group overall and, moreover, no effect on the aged rats when the results were stratified by memory status, documented in the water maze (Extended Data Fig. 5-1 C , D ). 10.1523/ENEURO.0422-25.2025.f5-1 Fig 5-1 Effects of sham and TMS treatment on sociability and social novelty index scores in aged rats subgrouped according to hippocampal memory in the water maze.

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