The therapeutic potential of ayahuasca in depression, generalized anxiety, and substance use disorders: modulation of the depressive burden in a longitudinal study.

Front Psychiatry · 2026 · PMC12894027 · PMID 41696466

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a clear trendno p-value reported

The analysis of MADRS scores over time revealed a clear trend of symptom reduction following the ayahuasca ritual, indicating a progressive decrease in depressive symptom severity among participants.

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