MALT1 Knockdown Alleviates Multiorgan Injury and Inflammation Through Inhibiting TAK1/NF-κB Signaling Pathway-Mediated T-Helper 1 and 17 Differentiations in LPS-induced Inflammation.

In the KD-MALT1 group, TNF-α ( P < 0.05), IL-6 ( P < 0.01), and IL-17 A ( P < 0.05) were decreased compared with the KD-Ctrl group, while the difference in IFN-γ did not reach statistical significance between the two groups ( P > 0.05) (Fig. 3 A).

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The proportion of Th1 cells in CD4 + T cells of PBMCs showed a decreasing trend in KD-MALT1 group compared with KD-Ctrl group, but did not achieve statistical significance ( P > 0.05) (Fig. 3 B), whereas that of Th17 cells was lower in the KD-MALT1 group compared with KD-Ctrl group ( P < 0.05) (Fig. 3 C).

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