Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33/ST2 pathway.

Compared with HIRI mice, lactate-pretreated mice exhibited lower levels of cleaved Caspase-3 and a significantly increased BCL2/BAX protein ratio, and cleaved PARP levels were lower in the lactate group, although this difference did not reach statistical significance.

also in 111,027 other papers

Unexpectedly, oxamate treatment during H/R did not aggravate, but instead alleviated hepatocellular injury, as evidenced by reduced ALT and AST in the culture supernatant (Figure S4C), and was associated with a decreasing trend in IL-33 release (Figure S4D).

also in 47,180 other papers