Concurrent Alterations in DNA Methylation and RNA m6A Methylation During Epigenetic and Transcriptomic Reprogramming Induced by Tail Docking Stress in Fat-Tailed Sheep.

Animals (Basel) · 2026 · PMC12896734 · PMID 41681462

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a pronounced trendno p-value reported

At the DNA level, the tail-docked group exhibited a pronounced trend of hypomethylation across multiple functional genomic regions, including promoters, exons, and introns.

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did not reach statistical significanceno p-value reported

The analysis revealed that downregulated DMRs displayed higher statistical significance, although a large number of DMRs did not reach statistical significance.

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