Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Differential Biomarkers of Response to Dimethyl Fumarate and Ocrelizumab in Multiple Sclerosis.

Int J Mol Sci · 2026 · PMC12897660 · PMID 41683864

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

This difference was highly significant ( p < 0.001).

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did not reach statistical significanceno p-value reported

In patients treated with HETAs, only NfL levels were higher in NR patients compared to R patients, although this difference did not reach statistical significance.

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a decreasing trendno p-value reported

This difference between MS patients and healthy controls diminished after one year of treatment (T1), showing a decreasing trend in both NfL and GFAP levels after treatment compared to baseline.

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an increasing trendno p-value reported

We found that sNfL levels are significantly higher in NR (10.6 pg/mL) compared to R patients (8.4 pg/mL) with p = 0.007, while sGFAP levels exhibit only an increasing trend in NRs (134.6 pg/mL) compared to Rs (119 pg/mL), ( Figure 3 A,B).

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