Longitudinal Analysis of Mitochondrial D-Loop Methylation and Copy Number in Peripheral Blood: Epigenetic Signatures of Alzheimer's Disease Progression and Aging.

Int J Mol Sci · 2026 · PMC12898004 · PMID 41683898

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0830

boldest claim

The sentences

an increasing trendp ≤ 0.001actually significant

In particular, the T0–T2 comparison was highly significant and showed an increasing trend ( p ≤ 0.001), while T0–T1 ( p = 0.063) and T1–T2 ( p = 0.072) showed trends toward significance, also in an increasing direction.

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highly significantp ≤ 0.001actually significant

The T0-T2 comparison was highly significant ( p ≤ 0.001), and T1-T2 also showed a significant difference ( p = 0.007), whereas T0-T1 did not reach significance ( p = 0.219).

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did not reach statistical significancep > 0.05actually significant

All other comparisons did not reach statistical significance (all p > 0.05).

also in 111,027 other papers

a trend toward significancep = 0.056so close (0.05 < p ≤ 0.1)

The comparison between Group 2 (HC-MCI-AD) and Group 3 (MCI-MCI-AD) showed a trend toward significance ( p = 0.056) but did not reach the conventional threshold.

also in 3,729 other papers

a trend towards significancep = 0.083so close (0.05 < p ≤ 0.1)

The comparison between Group 2 (HC-MCI-AD) and Group 3 (MCI-MCI-AD) showed a trend towards significance ( p = 0.083) but did not exceed the conventional threshold.

also in 2,760 other papers

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