Shifting paradigm in locally advanced resectable gastric and gastroesophageal junction cancers.

World J Gastrointest Oncol · 2026 · PMC12898232 · PMID 41695924

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

did not reach statistical significanceP = 0.054so close (0.05 < p ≤ 0.1)

Median EFS was also numerically higher (30 months vs 22 months and 25 months, respectively) but did not reach statistical significance ( P = 0.054).

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highly significantno p-value reported

Data from multiple observational studies in G/GEJ cancers consistently show that the detection of ctDNA after complete resection (R0) is a highly significant prognostic factor, associated with a markedly increased risk of recurrence (hazard ratios ranging from 2.0 to 12.5 across studies)[ 19 ].

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