Reexamining the Role of Amyloid β Clearance from the Brain: Exporting Labile Iron from the Interstitial Fluid Performs a Protective Function.

For example, mice deficient in APP showed a trend to be more susceptible to infection by Salmonella enterica serotype Typhimurium [ 145 ], but it is unknown if more labile iron was available for infection or if the effect was due to the absence of amyloid β, which can have antibacterial effects independent of iron capture. 11.

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