Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domain.

PLoS Pathog · 2026 · PMC12900429 · PMID 41662358

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did not reach statistical significanceno p-value reported

We detected significantly higher induction of IFNB1 (~5-fold) in cells infected with the CA07-PA(38T) virus compared to the WT, and on average a 2-fold increased IFNB1 transcript levels in CA07-PA(38M) infected cells which did not reach statistical significance ( Fig 4H ).

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