A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification.

Nat Genet · 2026 · PMC12900647 · PMID 41663806

Europe PMC DOI

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0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

did not reach statistical significanceP = 0.10so close (0.05 < p ≤ 0.1)

However, due to the limited number of bulk RNA-seq profiles available, the SPP1 expression difference compared to MC ben-1 did not reach statistical significance (log 2 fold change 1.7, P = 0.10, false discovery rate (FDR) P = 0.21).

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