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Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations.

Front Mol Biosci · 2026 · PMC12900718 · PMID 41696582

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However, the differences did not reach statistical significance, a finding that is likely attributable to the limited sample size. 3.3 Higher serum ADAM17 levels indicated poor renal function in MM patients To further investigate the potential of serum ADAM17 in characterizing disease status in MM patients, we demonstrated its precise reflection of renal functi

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an increasing trendno p-value reported
Specifically, ADAM17 concentrations demonstrated an increasing trend corresponding with advancing disease stage.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.