Single-nucleus and spatial transcriptomics reveal intestinal cellular heterogeneity, differentiation, and cell communication mechanisms in SAP-induced intestinal injury.

Front Immunol · 2026 · PMC12901460 · PMID 41694378

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a decreasing trendno p-value reported

Immunofluorescence with quantitative image analysis showed a decreasing trend in the proportions of Olfm4 + and Lgr5 + intestinal stem cells co-expressing Hmga2 or Myb in SAP compared with controls, although these differences did not reach statistical significance ( Figure 5J , Supplementary Figure S8I ).

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did not reach statistical significanceno p-value reported

SAP was associated with compositional remodeling characterized by downward trends in Lgr5 + /Olfm4 + stem cells, TA1, goblet cells, and Paneth cells, with a reciprocal increase in enterocytes, although most proportion changes did not reach statistical significance at the animal level.

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