A cross-sectional exploratory study of rat sarcoma (Ras) activation in non-obese women with and without polycystic ovary syndrome.

EXCLI J · 2026 · PMC12901957 · PMID 41696438

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showed a trendno p-value reported

In comparison with our previous study, where BMI was stratified up to 29 kg/m 2 (Niinuma et al., 2025[ 31 ]), EGFR differed in both studies; fibroblast growth factor 8 (FGF8), FGFR1, IGF1 differed in the previous study and here they were either significantly different (IGF1, p=0.05) or showed a trend (FGF8, FGFR1) towards significance (0.06 and 0.07, respectively), but none remained significant after FDR testing.

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highly significantno p-value reported

In this study, the increase of VEFGA was highly significant but in real terms there was only a 1.2-fold increase that, on its own, is unlikely to be clinically significant but, in combination with other factors, may have clinical relevance.

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