A stage-specific cascade of neural dysfunction emotional conflict processing in major depressive disorder.

Psychol Med · 2026 · PMC12902179 · PMID 41622849

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

approached significancep = .075so close (0.05 < p ≤ 0.1)

The valence × congruency × group interaction approached significance ( F (1, 274) = 3.19, p = .075, η 2 p = .011).Simple effects analysis revealed a significant valence × congruency interaction in both HCs ( F (1, 100) = 19.94, p < .001, η 2 p = .166) and MDD group ( F (1, 174) = 5.06, p = .026, η 2 p = .028).

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marginally significantp = .077so close (0.05 < p ≤ 0.1)

The main effect of group was marginally significant ( F (1, 274) = 3.16, p = .077, η 2 p = 0.011), indicating a trend toward reduced accuracy in the MDD group.

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